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All Day


Four Points by Sheraton
Kalandergasse 1

The Threshold of Toxicological Concern, short TTC, is a concept for assessing the risk of single chemical exposure to human health. It establishes generic exposure thresholds based on chemical structure below which chemicals are assumed to be safely used. In the absence of toxicological data, regulators, academic scientists and industry experts are using the TTC to perform chemical risk assessments.

On October 17, 2013 the Food Packaging Forum held a workshop offering a platform for balanced information and scientific debate to decision makers and scientific experts. Participants were given an understanding of the relevant scientific background of the TTC concept, thus providing the ground for a balanced, science-based discussion about the TTC’s use in chemical risk assessment. The workshop was an excellent basis for discussing the TTC’s use in chemical safety assessment beyond food contact materials. 90% of respondents to the questionnaire collected after the meeting considered the content of the workshop excellent. Participants valued the wide variety fo speakers and views, as well as a high level of expertise present during the meeting.


1. Welcome, introduction and history of the TTC

Dr. Jane Muncke,
Food Packaging Forum, Switzerland

2. Cramer classes in the TTC – fit for purpose?

Dr. Susan Barlow,
Consultant and former member of EFSA’s Scientific Committee and
its TTC working group, UK

3. Making TTC fit for application – Chemical domain, in silico models and weight of evidence

Prof. Gerrit Schüürmann,
Helmholtz Centre for Environmental Research UFZ, and
Technical University Bergakademie Freiberg, Germany

4. Chronic toxicity testing

Dr. Chris E. Talsness,
Charité – Universitätsmedizin Berlin, Germany

5. Safety factors in chemical risk assessment

Dr. Olwenn Martin,
Brunel University, UK

6. Using the TTC in Europe for evaluation of substances ingested at low levels through food: Challenges and perspectives

Dr. Alexandre Feigenbaum,
ReSafe, France

7. Mixture toxicity and the TTC

Prof. Thomas Backhaus,
University Gothenburg, Sweden

8. Low dose effects, non-monotonic dose responses and endocrine disrupting chemicals

Dr. Pete Myers,
Environmental Health Sciences and Carnegie Mellon University, USA

9. How to assess non-intentionally added substances in food contact materials

Dr. Claudia Heppner,
EFSA, Head of food ingredients and packaging unit

10. Decision making under uncertainty: A view from philosophy

Dr. Karim Bschir,
Swiss Federal Institute of Technology ETH Zurich, Switzerland

11. Summary and outlook: existing needs and scientific issues

PD Dr. Martin Scheringer,
Swiss Federal Institute of Technology ETH Zurich, Switzerland