Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha-, beta-, and membrane-associated forms of estrogen receptor
BPA disrupts regulation of feeding behavior
Scientists show that exposure to low-dose BPA during fetal development interferes with leptin and hypothalamic feeding circuitry, disrupts regulation of feeding behavior, predisposes to obesity in later life
Guidelines for sample preparation needed
EU Commission’s Joint Research Centre publishes study on heavy metal contamination in canned vegetables, shows need for clear sample preparation guidelines to ensure harmonized compliance assessment
AOP-based computational models for regulatory toxicology
Review article by EU Commission’s Joint Research Centre and collaborators discusses development and use of computational prediction models for regulatory toxicology and how it can be supported by the Adverse Outcome Pathways framework
Predicting mutagenicity of chemicals in printed paper and board FCM
Scientists propose a strategy for prioritizing assessment of non-evaluated chemicals potentially present in printed paper and board FCM with help of quantitative structure-activity relationship (QSAR) models; identify 106 substances of highest concern
Strategy for less animal testing
Swedish Chemicals Agency publishes report on the replacement, reduction and refinement of animal experiments to assess chemical safety
Children exposed to lead from water and food
Formula-fed infants and toddlers in U.S. exposed to lead mainly from water and food, respectively, according to new report by Environmental Protection Agency
EFSA working group on recycling plastics: 15th meeting
Updated meeting minutes of EFSA’s CEF Panel working group on recycling plastics now available online
EFSA reevaluation of BPA: 3rd meeting
EFSA’s CEF Panel Working Group on BPA assessment protocol holds third meeting on the safety reevaluation of BPA; meeting minutes available online
FPF can coatings webinar: Video online
Food Packaging Forum held webinar on can coatings on February 7, 2017; video recording now available