A new study published in the open access peer-reviewed journal PloS One found bisphenol A (BPA) exposure to enhance atherosclerosis in rabbits. The researchers administered 400 µg BPA/kg/day over twelve weeks by gavage to Watanabe heritable hyperlipidemic (WHHL) rabbits. They found plasma lipids and body weight to not be influenced. However, the researchers detected an increase of 37% of advanced atherosclerotic lesions and increases in several other markers of atherosclerosis, as well as increases in the expression of stress and inflammation related genes in human umbilical cord vein endothelial cells. The number of macrophages in the rabbits was not modified by the exposure.
Fang, C. et al. (2014). “Bisphenol A exposure enhances atherosclerosis in WHHL rabbits.” PloS One (published online October 21, 2014).