Microbiome and chemical risk assessment

U.S. National Academy of Sciences’ report outlines research strategy to assess the need for chemical risk assessments to consider interactions between chemicals and microbiota when estimating human health effects

Regulatory status of non-animal approaches

U.S. NAS workshop suggests comparing non-animal tests to human, not rodent, data, predicts alternatives to soon replace whole-animal tests; ECHA sees “long-way” until regulatory acceptance of alternatives for complex endpoints

Utility of bioassays in safety assessment

Scientists demonstrate utility of bioassays in FCM safety assessment using 4-nonylphenol (4NP) as model substance; 4NP levels detected by bioassays considered relevant for safety assessment

In vitro testing of paper and board FCMs

Scientists test paper and board FCMs in 8 in vitro bioassays; all 20 samples showed positive responses in at least one of the assays; chemicals in paper and board FCMs require further investigation to ensure safety