Lack of ‘nano’ in OECD nanomaterials dossiers

NGO-commissioned study finds that OECD’s dossiers on 11 nanomaterials are of ‘little to no value’ in assessing risks; characterization of test materials in most cases ‘insufficient’ to ensure nano-specificity

BPA and autoimmune disorders

Scientists report evidence suggesting that immune reactivity to BPA bound to human tissue proteins may contribute to neurological autoimmune disorders

Antiandrogenic chemicals in food

Scientists review food components and contaminants that can act as (anti)androgens; in vitro-based computational model for interactions with androgen receptor identifies active chemicals in ToxCast dataset

EFSA study: Bioaccumulation and toxicity of mineral oils

New EFSA scientific study tests different mixtures of mineral oil saturated hydrocarbons (MOSH), relevant to human diet, in rats; bioaccumulation at low dose MOSH exposure in humans possibly underestimated; MOSH appear persistent in adipose tissue

In vitro bioassays for FCMs

Austrian research institute for chemistry and technology holds information event on bioassays for food contact materials on March 8, 2017 in Vienna

Academic research vs. guideline studies

Article in Science illustrates gap between academic researchers and regulators about scientific evidence use in assessment of chemicals’ health risks

Extranuclear actions of EDCs at low doses

Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha-, beta-, and membrane-associated forms of estrogen receptor

BPA disrupts regulation of feeding behavior

Scientists show that exposure to low-dose BPA during fetal development interferes with leptin and hypothalamic feeding circuitry, disrupts regulation of feeding behavior, predisposes to obesity in later life

AOP-based computational models for regulatory toxicology

Review article by EU Commission’s Joint Research Centre and collaborators discusses development and use of computational prediction models for regulatory toxicology and how it can be supported by the Adverse Outcome Pathways framework

Mutagenicity of chemicals in printed paper and board FCMs

Scientists propose strategy for prioritizing assessment of non-evaluated chemicals potentially present in printed paper and board FCMs with help of quantitative structure-activity relationship (QSAR) models; identify 106 substances of highest concern