High throughput in vitro testing of BPA analogues

Scientists analyze estrogen- and androgen-like properties of BPA analogues using cell-based high throughput microscopy-employing tests; demonstrate anti-estrogenic and anti-androgenic properties of TMBPF

In vitro testing of FCMs: Current science and future challenges

New scientific study by FPF summarizes research on alternative toxicity testing of FCMs, finds approach promising and feasible; sample preparation methods need to be optimized and standardized; employed assays should be of clear human health relevance

Phthalates’ impact on human health

Scientists compile comprehensive review on phthalates, focus on human health effects observed in epidemiological and clinical studies

Genotoxic chemicals in coatings

Scientists compile inventory of compounds potentially used in coatings; 1,976 substances have no (recent) toxicological evaluation; subset analyzed by in silico tools and literature search, 10 compounds designated as ‘high concern’

In vitro testing of paper and board FCMs

Scientists test paper and board FCMs in 8 in vitro bioassays; all 20 samples showed positive responses in at least one of the assays; chemicals in paper and board FCMs require further investigation to ensure safety

DEHP increases BPA exposure

Scientists show that diethylhexyl phthalate (DEHP) leads to higher accumulation of bisphenol A (BPA) in reproductive tissues of mice, likely due to competition for detoxification enzymes

New test methods for EDCs needed

JRC expert survey identifies gaps in test methods for evaluating endocrine disruptors; new methods for thyroid, metabolic, immune disorders, as well as hormone-related cancers seen as priority

Regulatory acceptance of non-animal tests

U.S. federal agencies’ committee releases draft roadmap for further developmnt of alternative testing approaches, aimed at improving regulatory acceptance; public consultation open until August 31, 2017

Hazard assessment of FCM extracts

Scientists review studies on the use of select bioassays to assess hazard of food contact materials; bioassays considered a useful addition to targeted chemical analysis, especially in the assessment of finished materials and articles

Cardiotoxicity of BPA

CLARITY-BPA study finds BPA exposure to increase incidence and severity of cardiomyopathy, promoting myocardial degeneration; BPA’s cardiotoxicity could be caused by adverse vascular events