AOPs in Integrated Approaches to Testing and Assessment

OECD publishes guidance on the use of Adverse Outcome Pathways (AOPs) in developing Integrated Approaches to Testing and Assessment (IATA); AOPs to support chemical grouping, development of models, test methods, and testing strategies, and interpretation of test results

Reference guide on health effects of chemicals

Integrative Environmental Medicine book provides comprehensive overview of chemical effects on health, outlines resources and tools helping to reduce exposure and risks

MigraTox: Optimizing in vitro testing of FCMs

Austrian Research Institute for Chemistry and Technology (OFI) initiates MigraTox project to work on optimizing and standardizing sample preparation and bioassays for in vitro testing of food contact materials; focuses on genotoxicity assays; calls on industrial partners to collaborate and provide samples

Fluorene-9-bisphenol is anti-estrogenic

Scientists examine occurrence and effects of bisphenol A substitute, fluorene-9-bisphenol (BHPF); BHPF present in about half of ‘BPA-free’ bottles; BHPF is anti-estrogenic, causes smaller wombs, miscarriages, and smaller pups in mice

Lack of ‘nano’ in OECD nanomaterials dossiers

NGO-commissioned study finds that OECD’s dossiers on 11 nanomaterials are of ‘little to no value’ in assessing risks; characterization of test materials in most cases ‘insufficient’ to ensure nano-specificity

BPA and autoimmune disorders

Scientists report evidence suggesting that immune reactivity to BPA bound to human tissue proteins may contribute to neurological autoimmune disorders

Antiandrogenic chemicals in food

Scientists review food components and contaminants that can act as (anti)androgens; in vitro-based computational model for interactions with androgen receptor identifies active chemicals in ToxCast dataset

EFSA study: Bioaccumulation and toxicity of mineral oils

New EFSA scientific study tests different mixtures of mineral oil saturated hydrocarbons (MOSH), relevant to human diet, in rats; bioaccumulation at low dose MOSH exposure in humans possibly underestimated; MOSH appear persistent in adipose tissue

In vitro bioassays for FCMs

Austrian research institute for chemistry and technology holds information event on bioassays for food contact materials on March 8, 2017 in Vienna

Academic research vs. guideline studies

Article in Science illustrates gap between academic researchers and regulators about scientific evidence use in assessment of chemicals’ health risks