Study finds developmental toxicity in rats for hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX); exposure results in reduced pup birth weights, increased pup liver weight, and reduced neonatal survival; similar adverse effects to other per- and polyfluoroalkyl substances; knowledge gaps regarding clearance rate and human half-life
December 15, 2020
Using ToxCast data to assess food chemicals
Scientists explore the utility of-throughput screening data for hazard assessment and toxicological read-across of food-relevant chemicals; observe some biological targets to lack validated toxicity associations; demonstrate application in identifying out-of-domain compounds
November 30, 2020
FPF publishes food contact chemicals database
Researchers led by the Food Packaging Forum (FPF) publish new database identifying over 12,200 distinct chemicals that could be used in manufacture of food contact materials and articles; 29% lacking openly accessible toxicity data; 608 identified as most hazardous, prioritized for substitution; published study and database freely accessible
November 10, 2020
JRC proposes improved testing strategies
EU’s Joint Research Centre (JRC) publishes study identifying chemical testing strategies that require fewer tests, reduce need for animal testing; based on data on biocide and plant protection products, could be expanded for use across other product types
October 28, 2020
‘The trouble with plastics’
Special issue of peer-reviewed journal Birth Defects Research presents a collection of articles on plastics’ effects on human health, with a particular focus on early development
October 26, 2020
Clarifications to REACH data requirements
European Commission publishes draft amendment to REACH text dealing with information requirements for chemicals dossiers; feedback accepted until November 16, 2020
October 16, 2020
Recent studies on EDCs and cardiovascular health
Emerging evidence and systematic analyses highlight adverse effects of bisphenols and phthalates on cardiovascular health; meta-analysis of US National Health and Nutrition Examination Survey data from 2003-2016 finds significant association of cardiovascular disease with bisphenol A; prenatal exposure particularly detrimental; calls for more mechanistic research, evaluation of cardiovascular safety profiles for substitution chemicals
September 24, 2020
New York Times investigates PFAS and pregnancy
Publishes second article in three-part series on hazardous chemical exposure at home; provides overview of research on toxicity of per- and polyfluoroalkyl substances (PFAS) to developing fetuses, young children; profiles US families with high PFAS concentrations in drinking water, efforts to restrict uses
September 18, 2020
In vitro toxicity of bioplastics and plant-based materials
Scientists investigate in vitro toxicity of extracts from bioplastics and plant-based food contact articles; find strongest toxicity induced by cellulose- and starch-based products; emphasize similar toxicity profiles among bio-based, biodegradable, and conventional plastics
July 20, 2020
Combined evidence supports low-dose effects of BPA
Scientists integrate and interpret data from 8 of the 14 academic studies completed under the CLARITY-BPA project; link bisphenol A (BPA) exposure to impacts across multiple organs including brain, heart, prostate, mammary gland, ovaries; strengthen confidence in low-dose effects of BPA; co-authors to present results in webinar on July 21, 2020
