Sublingual absorption leads to free BPA in serum of test animals, delivers plausible explanation for previous human biomonitoring findings
News Article
June 13, 2013
News Article
March 7, 2013
New study shows novel effects of low dose BPA exposures
Early life exposures to low doses of BPA studied in mice and linked to significant dose-dependent changes in animals’ biochemical response
News Article
May 4, 2020
RIVM studies argue applied maximum doses too low
Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines
News Article
November 28, 2022
What should be included in UN Plastics Treaty negotiations?
International negotiators prepare for first meeting to negotiate the UN treaty to end plastic pollution; scientists, civil society organizations, and governmental bodies publish reports proposing suggestions for what and how to negotiate; many reports support including controls on chemical additives as part of the treaty
News Article
August 31, 2023
Microplastics can lead to behavioral changes in mice
Scientists find polystyrene microplastics reduce cell viability, translocate in the body, modify mice behavior, and change their liver and brain immune markers after short-term exposure; effects potentially age-dependent; two reviews summarize nano- and microplastic impacts on fertility and potential implications
News Article
September 28, 2018
Regulatory relevance of nonmonotonic responses
Scientists discuss different cases of nonmonotonic dose-response curves and their relevance for regulatory decision-making; nonmonotonicity occurring at low doses challenges current approach to determining low-dose ‘safe’ exposure levels from high-dose toxicity testing
News Article
April 1, 2014
Standardizing Benchmark Dose (BMD) calculations
New study assesses reliability of standardized Benchmark Dose calculations, more dose groups and lower number of animals make for better BMD model
News Article
October 7, 2016
Adverse health effects of low-dose mixtures
Scientists evaluate health effects of a mixture of 27 environmental chemicals in rats exposed to low concentrations comparable to current human exposure levels; find effects on weight, histology, gene expression in the liver, and metabolome of blood plasma
News Article
June 26, 2014
Risk assessment of EDCs: Exposure route questioned
Researchers publish review discussing oral dosing via gavage for risk assessment of endocrine disrupting chemicals; criticize human risk assessment requirements for relevant exposure route
News Article
July 29, 2021
Study finds microplastics induce reproductive toxicity in male mice
Study investigates reproductive toxicity of environmental concentrations of polystyrene (PS) microplastics to male mice; further examines underlying molecular mechanism; study is first to find long-term PS microplastic exposure affects sperm quality and testosterone levels in mice
