The non-profit organization International Chemical Secretariat (ChemSec), dedicated to increase chemical safety, published a version 2.1 of its Substitute it now! (SIN) list on February 14, 2013. ChemSec added 249 substances to the SIN database now amounting to 621 Substances and Substance groups of Very High Concern. Of the total 621 substances and substance groups (a total of 803 compounds) now on the SIN list, 59 compounds are also authorized as indirect food additives under the US Code of Federal Regulations Title 21; and 33 are authorized in Europe under Annex I for the use as monomers and/or additives in plastic food contact materials. ChemSec added 225 complex hydrocarbon distillates, 9 substances that are carcinogenic, mutagenic or toxic to reproduction and 15 substances that were recently added to the official European Candidate List of Substances of Very High Concern (SVHCs) and which were previously not included in the SIN list.

The SIN list is a list created by ChemSec to inform member states and enterprises of substances that qualify as SVHCs under the criteria established by the EU chemical regulation, REACH. The substances identified are substances that can cause cancer, alter DNA or damage reproductive systems. ChemSec has no legal mandate for the creation of this list of SVHCs and substances are not bound to be put on the Candidate List of SVHCs. However, the European Commissioner for Environment, Janez Potočnik stated in 2011 that "the recently published second edition of the SIN list […] should indicate to you the substances the European Commission will take into consideration for placement on the candidate list."

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ChemSec Press Release on SIN list 2.1 (pdf)