A review article published in the January 2015 issue of the peer-reviewed European Journal of Clinical Investigation discusses bisphenol A (BPA, CAS 80-05-7) induced epigenetic alterations that might be associated with cancer. Previous studies have shown that BPA exposure can lead to the development of several chronic human diseases, including cancer. Therefore, researchers from the University of Coimbra, Portugal reviewed published scientific articles, which elucidate and link some of the information already available about BPA and related epigenetic alterations. The authors highlight a number of studies indicating that short-term administration of either low or high-doses of BPA may increase the risk of cancer because of epigenetic changes. The exact mechanisms of action are, however, not yet completely understood. More studies considering realistic everyday life BPA exposures are needed to define a real tolerable daily intake (TDI) as well as to tighten regulations, the authors stress.

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 Ferreira, L.L. et al. (2015) “Bisphenol A as epigenetic modulator: setting the stage for carcinogenesis?European Journal of Clinical Investigation 45, S1: 32–36 (free article).