On November 29, 2016 the U.S. Environmental Protection Agency (EPA) published a press release announcing ten chemicals that will be evaluated for potential risks to human health and the environment. Under the Toxic Substances Control Act (TSCA) that was modernized on June 22, 2016 (FPF reported), EPA is now required to perform a risk assessment for existing chemicals to be able to judge whether they “present an unreasonable risk of injury to health or the environment.” As a first step, EPA plans to investigate ten substances with respect to their hazards, exposures, conditions of use, and the potentially exposed or susceptible subpopulations. The substances were selected based on their hazards and potential exposures. Furthermore, public discussions and ongoing risk assessments were considered. Within the next six months, EPA is going to release scoping documents for all substances.

Eight of the ten substances are currently authorized as indirect food additives in the U.S., whereas six of the substances are listed on European legal lists or inventories of substances used to produce food contact materials.

SubstanceCAS No.U.S.:
Substance listed as
Substance listed on
EPA: Hazard information
123-91-1Indirect food additiveFACETPossible human carcinogen
1-Bromopropane106-94-5Possible human carcinogen
AsbestosIndirect food additiveKnown human carcinogen;
acute and chronic toxicity from inhalation exposures
Carbon tetrachloride56-23-5Indirect food additiveESCOProbable human carcinogen
Cyclic aliphatic bromide clusterAcute aquatic toxicity
Methylene chloride75-09-2Direct & indirect food additive; colorFACETProbable human carcinogen
N-Methylpyrrolidone872-50-4Indirect food additiveAnnex I of (EU) No 10/2011; ESCO; FACETReproductive toxicity
Pigment violet 2981-33-4Indirect food additiveFACETAquatic toxicity
Tetrachloroethylene127-18-4Indirect food additiveProbable human carcinogen
Trichloroethylene79-01-6Direct & indirect food additive; flavorFACETProbable human carcinogen

Read more

EPA (November 29, 2016). “EPA names first chemicals for review under new TSCA legislation.

EPA (November 2016). “Evaluating risk of existing chemicals under TSCA.

The Hill (November 29, 2016). “EPA to consider banning asbestos, other chemicals.

Keller and Heckman LLP (November 30, 2016). “Announcement and implications of first 10 chemicals to undergo risk evaluation.

Jessica Lyons Hardcastle (November 30, 2016). “EPA names first chemicals to review under TSCA reform. Environmental Leader

Kelly Franklin (November 30, 2016). “EPA names first ten chemicals for new TSCA evaluations.” Chemical Watch