In an article published on June 30, 2015 the industry trade association American Chemistry Council (ACC) responds to the recently released results of the U.S. Environmental Protection Agency’s (EPA) Endocrine Disruptor Screening Program (EDSP). In a first step of EDSP, EPA did a screening of 52 pesticide chemicals (active and inert ingredients) to determine whether the chemicals have the potential to interact with the estrogen, androgen or thyroid hormonal pathways (Tier 1). EPA used a battery of 11 assays, five in vitro and six in vivo. Also, they took into account other scientifically relevant information, including general toxicity data and open literature studies of sufficient quality. For 18 chemicals EPA found potential endocrine activity that requires additional testing (Tier 2).
ACC approves of the EDSP Tier 1 results and praises EPA’s weight-of-evidence approach to evaluate the risk of exposure to endocrine disrupting chemicals (EDCs). For two solvents of specific interest to ACC, isophorone (CAS 78-59-1) and acetone (CAS 67-64-1), EPA’s Tier 1 screening concluded that there is no convincing evidence of potential endocrine activity and no further testing is required.
EPA’s EDSP was also the topic of a webcast hosted by the Collaborative on Health and Environment (CHE) on June 30, 2015.
ACC (June 30, 2015). “ACC Applauds EPA Milestone in Endocrine Disruptor Screening Program.”
EPA (June 30, 2015). “Endocrine Disruptor Screening Program (EDSP).”
EPA (July 2, 2015). “Endocrine Disruptor Screening Program Tier 1 Assessments.”
CHE (June 30, 2015). “News from the US EPA Endocrine Disruptor Screening Program.”