On November 24, 2014 the European Commission’s Joint Research Centre (JRC) published a report that gives a comprehensive overview of methodological approaches and regulatory requirements for assessing mixture effects of chemicals. Humans and the environment are daily exposed to multiple chemicals at the same time. It is stated in the report that the combined effects of chemical mixtures need to be evaluated in addition to the effects of the individual mixture components (also previously summarized in a background article by the FPF). The report entitled “Assessment of mixtures – review of regulatory requirements and guidance” offers an up-to-date overview of the current EU regulations, risk assessment regimes and requirements regarding potential mixture effects. Further, it focuses on guidance on mixture toxicity assessment available in the EU and in other countries (U.S., Canada). Existing guidance documents from major international bodies such as the World Health Organization (WHO) and the Organisation for Economic Co-operation and Development (OECD) are also covered. Overall, the report promotes a basis for the safe use of chemicals and mixtures covered under EU legislation.

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JRC (November 24, 2014). “Assessment of mixtures – review of regulatory requirements and guidance.

JRC News (November 24, 2014). “Towards improved safety assessment of combined exposure to chemicals.