On July 14, 2015 the European Commission’s (EC) Joint Research Centre (JRC) announced that the JRC-run EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) published a new strategy to integrate toxicokinetic data obtained through non-animal testing in computational models of the human body (PBTK models). Four important processes that drive the fate of a chemical within the body are absorption, distribution, metabolism and excretion (ADME processes). The strategy aims to 1) develop and standardize more in vitro methods for testing chemicals’ ADME processes in humans, 2) establish a collaborative web-based environment for toxicokinetic modeling (in silico) which facilitates the development and use of such models and provides freely available kinetic modeling tools and databases for in silico, in vitro and in vivo data, and 3) stimulate generation and collection of toxicokinetic data to fill these public databases. The EURL ECVAM strategy supports the EU directive to phase out animal testing for scientific purposes (Directive 2010/63/EU).
JRC (July 14, 2015). “New strategy to track how chemicals behave in the human body.”
Bessems, J. et al. (2015). “EURL ECVAM strategy for achieving 3Rs impact in the assessment of toxicokinetics and systemic toxicity.” JRC – EURL ECVAM (pdf)