In a news article published in the scientific journal Environmental Health Perspectives (EHP), Julia Barrett, science writer for EHP, explains what the new sublingual findings (previously reported on by the FPF) mean for bisphenol A (BPA) research. In Barrett’s article, Laura Vandenberg, post-doctoral fellow at Tufts University Center for Regenerative and Developmental Biology, points out that most studies on environmental contaminants including BPA rely on the gavage method, circumventing sublingual exposure. It was previously thought that BPA would be rapidly converted into biologically inactive BPA metabolites, which could be readily excreted. The European Food Safety Authority’s (EFSA) tolerable daily intake (TDI) of 0.05mg/kg is based on this assumption. If, as shown in the new study, BPA is readily absorbed over the mucous membrane in the mouth, biologically active BPA would be present in the body over extended periods of time. According to co-author of the study Pierre-Louis Toutain, professor of physiology and therapeutics at the National Veterinary School of Toulouse, France, states that the finding of increased bioavailability should raise “some questions and possibly lead some agencies to reconsider their risk analysis of BPA”.
FPF article "New study shows impact of oral dosing on free BPA levels"