The peer-reviewed journal Food Additives & Contaminants: Part A published on November 15, 2013 the article “A novel safety assessment strategy for non-intentionally added substances (NIAS) in carton food contact materials”. The authors, Sander Koster and colleagues, work at the Netherlands Organisation for Applied Scientific Research TNO. In their article, Koster et al. present their new Complex Mixture Safety Assessment Strategy (CoMSAS) for the evaluation of unknown non-intentionally added substances (NIAS) in complex migration extracts from food contact materials (FCM). The CoMSAS facilitates the safety evaluation of unknown substances by proposing the use of an exposure limit of 90 µg/day, based on the Threshold of Toxicological Concern (TTC). Furthermore, the CoMSAS combines a variety of analytic tools to screen for unknown substances in the migration extract of FCMs, which are subsequently tested for their toxicity in bioassays. The researchers demonstrate the work load reduction of their procedure in the evaluation of unknown NIAS’ in three samples of carton FCMs. Koster and colleagues state that their strategy includes the elucidation of chemicals in complex mixtures, however does not account for the combination toxicity of complex mixtures.

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FPF report “New safety assessment procedure for unknown NIAS