Researcher from the University of La Rioja showed that focused ultrasonic solid-liquid extraction (FUSLE) combined with reverse-phase ultra-performance liquid chromatography (UPLC) and quadruple-time of flight mass spectrometer (Q-TOF-MS) could be used to accurately and time efficiently determine bisphenol A (BPA), bisphenol F (BPF), bisphenol A diglycidyl ether (BADGE) and bisphenol F diglycidyl ether (BFDGE) concentrations in paper and board (Pérez-Palacios et al. 2012). The carrying out of the entire method only takes 4 minutes in comparison to the 12 and 17 minutes of traditional liquid chromatography.

All tested food packaging materials contained BPA, but the analyzed paper tablecloth, pizza carton and packaging box were found to have the highest concentrations of BPA. BPF was only detected in the popcorn bag and paper tablecloth, but concentrations were below the limit of quantification.


Pérez-Palacios, D., M. Á. Fernández-Recio, C. Moreta and M. T. Tena (2012). "Determination of bisphenol-type endocrine disrupting compounds in food-contact recycled-paper materials by focused ultrasonic solid–liquid extraction and ultra performance liquid chromatography-high resolution mass spectrometry." Talanta 99(0): 167-174.