A review article published on June 19, 2017 in the peer-reviewed Journal of Hazardous Materials focuses on phthalates and their impacts on human health. Sailas Benjamin and colleagues from the Department of Bioengineering, Nagaoka University of Technology, Japan, compiled the evidence from epidemiological investigations and major clinical studies looking at adverse effects of phthalates and phthalate metabolites in humans.

The addressed health hazards included effects of phthalates in children and adolescents, reproductive toxicity in adults, as well as insulin resistance and type II diabetes, obesity, allergy, asthma, cancer, and epigenetic modulation. In addition, the authors provided description of major phthalates and their uses, along with information on phthalate exposure routes and biomonitoring. They also discussed risk assessment for phthalates with a special emphasis on endocrine disruption, and described plausible molecular mechanisms of phthalates’ actions through peroxisome proliferator activation receptors (PPARs).


Benjamin, S., et al. (2017). “Phthalates impact human health: Epidemiological evidences and plausible mechanism of action.Journal of Hazardous Materials (published June 19, 2017).