According to a news release published on February 25, 2015, the European Chemicals Agency (ECHA) amended the Annexes VIII, IX and X of the European Chemicals Regulation REACH. The Extended One-Generation Reproductive Toxicity Study (EOGRTS, OECD Test Guideline 443) has now become the standard information requirement for reproductive toxicity. EOGRTS replaces the two-generation reproductive toxicity study (OECD Test Guideline 416). The European Commission (EC) highlights that compared to the old test, EOGRTS uses fewer animals in most cases. Further, it generates more information particularly about the effects of potentially endocrine disrupting chemicals (EDCs). The updated annexes will enter into force on March 13, 2015.
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ECHA (February 25, 2015). “Information requirements for reproductive toxicity changed.”
EC (February 21, 2015). “Commission Regulation (EU) 2015/282 of 20 February 2015 amending Annexes VIII, IX and X to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) as regards the Extended One-Generation Reproductive Toxicity Study (Text with EEA relevance).” Official Journal of the European Union L 50, 1.
EC (February 24, 2015). “REACH Implementation.”
