On January 14, 2019, regulatory news provider Chemical Watch published an article reporting about a systematic review of animal data for diisobutyl phthalate (DIBP, CAS 84-69-5). The review article by scientists from the US Environmental Protection Agency (EPA) is seen as “a step forward in the Integrated Risk Information System’s (IRIS) assessment of the substance.” This is the first reported formal progress within the IRIS program since 2014.
The review’s authors “identified 19 rat and mouse studies for inclusion in the systematic review and found “robust” evidence that DIBP causes male reproductive and developmental toxicity.” Furthermore, “‘slight’ evidence for female reproductive toxicity and effects on the liver” as well as “‘indeterminate’ evidence for carcinogenicity and effects on the kidney” were found.
From June 2020, DIBP along with three other phthalates (DEHP, BBP, and DBP) will be restricted in the EU in any plasticized material in articles used by consumers or in indoor areas, however this restriction does not cover food contact materials (FPF reported).
Read more
Chemical Watch (January 14, 2019). “DIBP systematic review suggests US IRIS assessment progress.”
US EPA. “Diisobutyl phthalate (DIBP).”
Reference
Yost, E., et al. (2018). “Hazards of diisobutyl phthalate (DIBP) exposure: A systematic review of animal toxicology studies.” Environment International (published December 25, 2018).
