On January 9, 2015 the U.S. National Toxicology Program’s (NTP) Office of Health Assessment and Translation (OHAT) published a handbook for the development of systematic reviews. OHAT uses such reviews for literature-based health assessments of environmental substances. The handbook is considered to be a “living document”. Therefore, it will be updated to reflect refinements to methodological practices.

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U.S. NTP (January 9, 2015). “Handbook for conducting a literature-based health assessment using OHAT approach for systematic review and evidence integration.(pdf)