In an article published on May 22, 2014 on the U.S. Environmental Protection Agency’s (EPA) Connect Blog Bob Kavlock elaborated on EPA’s efforts to advance chemical testing using computer screening models and automated processes. The deputy assistant administrator for science in the EPA’s Office of Research and Development points to both the computational toxicology (CompTox) and the toxicity forecaster (ToxCast) research projects lead by the EPA. He refers to a recently published study which conducted an evaluation of ToxCast’s predictive capacity using data of chemicals whose toxicity is known (Kleinstreuer et al. 2014). In the study EPA collaborated with the company BioSeek to evaluate the toxicity and therapeutic effect of 776 chemicals found in consumer products. According to Kavlock, ToxCast allows for a consistent and accurate prediction of chemical’s toxicity.
Bob Kavlock (May 22, 2014). “Advancing chemical testing by the thousands.”
Kleinstreuer, N.C. et al (2014).“Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms.” Nature Biotechnology (published online May 18, 2014).