Linda Birnbaum, the director of the US NIEHS and NTP believes that the Tiered Protocol for Endocrine Disruption (TiPED) provides a strong framework in the investigation of potential endocrine disrupting effects of new chemicals (Birnbaum, 2013). She welcomed the article by Schug et al. which was published in Green Chemistry in the beginning of December 2012 as a first step towards the use of inherently safe chemicals in consumer products (see FPF article). However, she also points out that the TiPED is no regulatory program. It is a voluntary tool which can be used by industrial chemists to design inherently safe new chemicals. Currently there are more than 83 000 chemicals on the market, and only very few of these have been evaluated for their endocrine disrupting potential.

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FPF article

Betts, K. S. (2013). “Tiered protocol for sussing out endocrine disruption.” Environ Health Perspect 121(1): a16.


Birnbaum, L. S. (2013). “Designing safer chemicals.” Environ Health Perspect 121(1): a9.

Schug, T. T., et al. (2013). “Designing endocrine disruption out of the next generation of chemicals.” Green Chemistry 15(1): 181-198.