On September 9, 2014 the U.S. National Institute of Health (NIH) published the videocasts of a workshop on Adverse Outcome Pathways (AOPs) held in Bethesda, U.S (September 3-5, 2014). AOPs are used to relate mechanistic data on chemical substances to adverse endpoints in humans. At the workshop, speakers addressed the translation from Mode of Action (MOA) to AOPs and presented different AOP activities carried out by the Organisation of Economic Co-operation and Development (OECD) and the U.S. Environmental Protection Agency (EPA). Further, researchers from different universities discussed how AOPs were used to predict specific endpoints including thyroid disruption, neurotoxicity, skin sensitization, lung injuries. The workshop intended to address how research on AOPs could be applied in regulation. The presentations are publicly available on the NIH website of VideoCasting and Podcasting.
NIHs (September 15, 2014). “Adverse Outcome Pathways: From research to regulation.”