A study by scientists from the New York University’s School of Medicine published in September 2012 found elevated levels of a common food contact substance, bisphenol A (BPA), to be associated with a higher risk for being overweight in children and adolescents. The study used nationally representative data from the National Health and Nutrition Examination Survey (NHANES) study collected in 6 to 19 year old US inhabitants. The study’s design does not permit conclusions regarding causation, however biological plausible explanations of how BPA may cause overweight or obesity do exist, making the study relevant and highlighting the need for further research.
Hazardous chemicals in food contact materials?
The Food Packaging Forum’s second annual workshop was dedicated to hazardous chemicals in food contact materials (FCMs). A recent study by the Food Packaging Forum revealed that known chemicals of concern are knowingly and intentionally used in the manufacture of FCMs. During the workshop, participants learned from internationally renowned scientific experts how hazardous chemicals are managed in FCMs, how their risk is assessed, how chemical analytical work helps to ensure the safety of food packaging, and what emerging issues are related to the risk of chemicals in FCMs. They also heard […]
Microplastic effects on colon cells, blood lymphocytes, and gut-liver axis
Two in vitro studies analyze plastic particle effects using human cells; find polystyrene (PS) particles change metabolism of human colon cells similar to a carcinogen; PS nanoplastics may have cytotoxic and genotoxic potential on human blood lymphocytes; mouse study indicates microplastics increase risk of insulin resistance; researchers calculate particle ingestion from takeaway containers
Scientists detect microplastics in amniotic fluid, effects on testicular aging
Two studies investigate microplastic presence or effects in female and male reproductive organs; small cohort study finds low number of microplastics to be present in human amniotic fluid besides the placenta; in vitro and mice in vivo study reports microplastics induce premature testicular aging and identifies underlying pathways
Carcinogenesis by low-dose chemical mixtures: way forward
Scientists summarize the knowledge on the combined contribution of low-dose chemical exposures to carcinogenesis, identify research gaps, recommend novel methodologies for research and risk assessment
EFSA: Non-monotonic dose response update
EFSA-commissioned review of non-monotonic dose response (NMDR) studies published; four substances relevant to food safety identified with potential for NMDR effects
Extranuclear actions of EDCs at low doses
Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha, beta, and membrane-associated forms of estrogen receptor
EFSA study: Bioaccumulation and toxicity of mineral oils
New EFSA scientific study tests different mixtures of mineral oil saturated hydrocarbons (MOSH), relevant to human diet, in rats; bioaccumulation at low dose MOSH exposure in humans possibly underestimated; MOSH appear persistent in adipose tissue
Mapping microplastics in the male reproductive system
Study provides an in-depth look at microplastics in the male reproductive system, analyzes human and mouse samples to chart concentrations and polymer types; finds microplastics in all human testes samples and majority of semen samples; larger plastic particles may get trapped in testis, leading to higher concentrations; identifies correlation between urbanization, home-cooked meals, and body scrub used to microplastics concentration
Combined evidence supports low-dose effects of BPA
Scientists integrate and interpret data from 8 of the 14 academic studies completed under the CLARITY-BPA project; link bisphenol A (BPA) exposure to impacts across multiple organs including brain, heart, prostate, mammary gland, ovaries; strengthen confidence in low-dose effects of BPA; co-authors to present results in webinar on July 21, 2020