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EFSA: Scientific Opinion on the impact of NMDR on risk assessment

European Food Safety Authority (EFSA) publishes opinion on the impact of non-monotonic dose responses (NMDRs) on human health risk assessment; if NMDR may be present, suggests further testing at the low end of the dose-response curve; recommends developing internationally agreed guidance and harmonized frameworks for ‘identifying and addressing’ NMDRs during risk assessments

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RIVM studies argue applied maximum doses too low

Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines