U.S. National Toxicology Program publishes final report on CLARITY-BPA core study and releases primary data from academic studies; joint report integrating findings from both research lines expected in fall 2019

Regulatory relevance of nonmonotonic responses

Scientists discuss different cases of nonmonotonic dose-response curves and their relevance for regulatory decision-making; nonmonotonicity occurring at low doses challenges current approach to determining low-dose ‘safe’ exposure levels from high-dose toxicity testing

EFSA BPA reevaluation: 1st meeting

EFSA’s CEP Panel Working Group on BPA safety reevaluation holds 1st meeting; minutes available online

EFSA conference 2018: Human health

Presentations at EFSA conference 2018 address advances and challenges in human health risk assessment; NTP official confirms that there will be a third CLARITY-BPA report integrating academic and regulatory studies

Human health impacts of dietary BPA exposure

Scientists review sources and levels of dietary exposure to bisphenol A, discuss health risks in exposed populations, call for targeted risk assessments in sensitive populations such as pregnant women and children

More retailers take part in annual ranking

Non-profit organization Safer Chemicals, Healthy Families includes 12 new retailers in annual ranking of progress towards eliminating toxic chemicals and using safer alternatives

BPA substitutes and chromosomal abnormalities

Mice exposed to low doses of BPA, BPS, diphenyl sulfone, BPF, BPAF exhibit chromosomal abnormalities that persist for several generations, according to new study in Current Biology

South Korea to prohibit BPA and phthalates in FCMs for children

South Korea notifies WTO of intended ban on bisphenol A, dibutyl phthalate, benzyl butyl phthalate in food contact materials for infants and young children

CLARITY-BPA webinars: Key messages

Carnegie Mellon University and FDA hold webinars on CLARITY-BPA academic research and guideline studies; FDA upholds importance of high-dose effects; academic researchers highlight significant low-dose effects

BPA human study: Effects on insulin response

First experimental study in humans finds low-dose exposure to bisphenol A alters insulin response to oral and IV glucose, possibly increases diabetes 2 risk