Non-monotonicity in risk assessment context

New study develops decision tree for assessing the strength of non-monotonic dose-response relationships

The EUROTOX/SOT debate: non-monotonicity and low dose effects

Scientists debate toxicological relevance of non-monotonic dose responses at low dose levels

US National Academy of Sciences urges redo of EPA’s draft risk paper

US National Academy of Sciences criticizes EPA report on adequacy of  toxicity testing for non-monotonic dose-responses

BPA masculinizes female brains

New results from FDA’s BPA low dose study show significant effects on female rat brains at lowest dose

Opinion: Precautionary principle threatens transatlantic trade

Wall Street Journal publishes MEP’s concerns that precautionary chemical regulation may harm transatlantic trade; earlier European debate on endocrine disruptors continued

Trade associations welcome BPA opinion

NAMPA and ACC respond to draft EFSA opinion on BPA, reassurance that BPA exposure is safe

EFSA publishes draft BPA opinion, part II

EFSA launches public consultation on BPA risk assessment opinion; recommends lowering of TDI; exposure levels considered safe

Scientists agree: Possibly no thresholds for EDCs

EC Chief Scientific Advisor meets experts, consensus on EDC definition and non-threshold hypothesis; implications for risk assessment remain under debate

Consensus on definition of low dose hypothesis needed

Summary article of 2012 Berlin low dose workshop shares workshop proceedings, consensus and disagreements, and shows proposed next steps required to advance risk assessment of EDCs

BPA causes metabolic changes at low, but not at high dose

New study investigates effects of prenatal BPA exposure on metabolism in vivo