Rethinking safe levels

Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity

Environmental toxicity of nanomaterials

German Environment Agency releases reports on aquatic toxicity and environmental fate of nanomaterials

FDA roadmap for predictive toxicology

U.S. FDA publishes roadmap to further develop predictive toxicology methods for risk assessment; public workshop to be held

Regulatory status of non-animal approaches

U.S. NAS workshop suggests comparing non-animal tests to human, not rodent, data, predicts alternatives to soon replace whole-animal tests; ECHA sees “long-way” until regulatory acceptance of alternatives for complex endpoints

BPA and analogues: Multiple targets and effects

Scientists highlight BPA’s interactions with multiple molecular targets besides estrogen receptor; growing body of evidence demonstrates similar pleiotropic actions of BPA substitutes such as BPS, BPF, BPAF and others

Controversy over DINCH

McGill University study shows exposure of pregnant rats to DINCH results in liver metabolism impairment and ‘testicular atrophy’ in the male progeny; BASF scientists depict study as ‘flawed,’ maintain that DINCH is safe for use in food contact applications

ANSES: Not enough data on TMBPF

ANSES finds insufficient data to conclude on the potential endocrine disrupting properties of tetramethylbisphenol F (TMBPF), a bisphenol A alternative

FPF Workshop 2017: Toxicological assessments and migration testing

Experts from academia, food industry and authorities present scientific and practical challenges in toxicological assessments and migration measurements

FCMs, gut health and risk assessment

New scientific article reviews food contact chemicals’ effects on gut permeability, microbiota, and immune responses; scientific justification for risk assessment assumptions questioned

Melamine’s effects beyond kidney

Scoping review identifies potential health effects of melamine other than renal damage, including impacts on neurological functions, behavior, reproduction, and growth