Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity
Environmental toxicity of nanomaterials
German Environment Agency releases reports on aquatic toxicity and environmental fate of nanomaterials
FDA roadmap for predictive toxicology
U.S. FDA publishes roadmap to further develop predictive toxicology methods for risk assessment; public workshop to be held
Regulatory status of non-animal approaches
U.S. NAS workshop suggests comparing non-animal tests to human, not rodent, data, predicts alternatives to soon replace whole-animal tests; ECHA sees “long-way” until regulatory acceptance of alternatives for complex endpoints
BPA and analogues: Multiple targets and effects
Scientists highlight BPA’s interactions with multiple molecular targets besides estrogen receptor; growing body of evidence demonstrates similar pleiotropic actions of BPA substitutes such as BPS, BPF, BPAF and others
Controversy over DINCH
McGill University study shows exposure of pregnant rats to DINCH results in liver metabolism impairment and ‘testicular atrophy’ in the male progeny; BASF scientists depict study as ‘flawed,’ maintain that DINCH is safe for use in food contact applications
ANSES: Not enough data on TMBPF
ANSES finds insufficient data to conclude on the potential endocrine disrupting properties of tetramethylbisphenol F (TMBPF), a bisphenol A alternative
FPF Workshop 2017: Toxicological assessments and migration testing
Experts from academia, food industry and authorities present scientific and practical challenges in toxicological assessments and migration measurements
FCMs, gut health and risk assessment
New scientific article reviews food contact chemicals’ effects on gut permeability, microbiota, and immune responses; scientific justification for risk assessment assumptions questioned
Melamine’s effects beyond kidney
Scoping review identifies potential health effects of melamine other than renal damage, including impacts on neurological functions, behavior, reproduction, and growth