Article in Science illustrates gap between academic researchers and regulators about scientific evidence use in assessment of chemicals’ health risks
February 10, 2017
Extranuclear actions of EDCs at low doses
Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha, beta, and membrane-associated forms of estrogen receptor
February 10, 2017
AOP-based computational models for regulatory toxicology
Review article by EU Commission’s Joint Research Centre and collaborators discusses development and use of computational prediction models for regulatory toxicology and how it can be supported by the Adverse Outcome Pathways framework
February 10, 2017
Mutagenicity of chemicals in printed paper and board FCMs
Scientists propose strategy for prioritizing assessment of non-evaluated chemicals potentially present in printed paper and board FCMs with help of quantitative structure-activity relationship (QSAR) models; identify 106 substances of highest concern
February 9, 2017
Strategy for less animal testing
Swedish Chemicals Agency publishes report on the replacement, reduction and refinement of animal experiments to assess chemical safety
February 7, 2017
Alternative testing strategies for nanomaterials
New OECD document discusses the use of alternative testing strategies in risk assessment of nanomaterials; makes recommendations to advance the field within coming years
January 25, 2017
Nanoparticles in food linked to cancer
Oral ingestion of titanium dioxide nanoparticles induces abnormal immune responses, preneoplastic lesions in the colon; scientists call for re-evaluation of risks from oral exposure to nanoparticles
December 23, 2016
Nanomaterials in FCMs: Open questions on migration and safety
Scientists review migration of nanomaterials from polymer-based FCMs, question suitability of migration testing conditions and diffusion-based models for estimation of nanomaterials migration, point to knowledge gaps regarding actions in human body
December 23, 2016
BPS affects maternal behavior
Exposure of pregnant and lactating mice to human-exposure-relevant dose of bisphenol S (BPS) impairs maternal behavior, what can lead to lower offspring survival; behavioral effects also seen in daughters of exposed mice
