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Scientists evaluate health effects of a mixture of 27 environmental chemicals in rats exposed to low concentrations comparable to current human exposure levels; find effects on weight, histology, gene expression in the liver, and metabolome of blood plasma
New study assesses reliability of standardized Benchmark Dose calculations, more dose groups and lower number of animals make for better BMD model
United Nations Environment Program (UNEP), industry organizations, scientific research groups, and civil society organizations publish flurry of reports and policy briefs in preparation for second meeting of the Intergovernmental Negotiating Committee on Plastic Pollution (INC-2); meeting takes place in Paris, France May 29 – June 2, 2023
Researchers publish review discussing oral dosing via gavage for risk assessment of endocrine disrupting chemicals; criticize human risk assessment requirements for relevant exposure route
Study investigates reproductive toxicity of environmental concentrations of polystyrene (PS) microplastics to male mice; further examines underlying molecular mechanism; study is first to find long-term PS microplastic exposure affects sperm quality and testosterone levels in mice
Varying levels of the four major brominated flame retardants found in polystyrene food contact materials
German risk assessment institute responds to Austrian stool study in communication addressing health risks from ingesting microplastics
German institute for risk assessment publishes position statement on melamine-formaldehyde resins, including tableware made with bamboo fibers; warns consumers against using such tableware with hot liquids; recommends lowering specific migration limit of formaldehyde in EU regulation from 15 to 6 mg/kg
Countries are submitting proposals to the UN Environment Program to guide Plastics Treaty development; US proposes treaty focus on downstream effects – reuse and recycling; proposal from 40-nation ‘high ambition coalition’ proposes setting up limits on polymer production, eliminating certain polymers and products; over 60 proposals received so far; stakeholder registration is open for the next negotiating meeting for the Plastics Treaty in Paris, France in May 2023
Rapid review assesses microplastics impacts on human cells and reports thresholds of effects lower than previously predicted; scientific study finds polystyrene (PS) microplastics to have nephrotoxic potential; reproduction and fertility study with mice reports PS microplastics to affect females more than males
