New York Times investigates PFAS and pregnancy

Publishes second article in three-part series on hazardous chemical exposure at home; provides overview of research on toxicity of per- and polyfluoroalkyl substances (PFAS) to developing fetuses, young children; profiles US families with high PFAS concentrations in drinking water, efforts to restrict uses

In vitro toxicity of bioplastics and plant-based materials

Scientists investigate in vitro toxicity of extracts from bioplastics and plant-based food contact articles; find strongest toxicity induced by cellulose- and starch-based products; emphasize similar toxicity profiles among bio-based, biodegradable, and conventional plastics

Combined evidence supports low-dose effects of BPA

Scientists integrate and interpret data from 8 of the 14 academic studies completed under the CLARITY-BPA project; link bisphenol A (BPA) exposure to impacts across multiple organs including brain, heart, prostate, mammary gland, ovaries; strengthen confidence in low-dose effects of BPA; co-authors to present results in webinar on July 21, 2020

ECHA report on alternatives to animal testing

Fourth report from the European Chemicals Agency (ECHA) finds little change since 2017, number of alternative testing adaptations continuing to increase; read-across most commonly applied followed by data-waiving and weight of evidence approaches

Webinar on key characteristics of hazardous chemicals

Food Packaging Forum holds webinar with presentation from Martyn Smith on the identification of key characteristics to support chemical evaluation; introduces concept and recent key publications; recording now available to watch

Webinar on computational predictive toxicology projects

American Society for Cellular and Computational Toxicology (ASCCT) to hold webinar on May 26, 2020, discussing three recently completed projects developing collaborative in silico toxicology models

Online colloquium on IATA for toxicology assessment

Society of Toxicology (SOT) and US Food and Drug Administration (FDA) to co-host colloquium on Integrated Approaches to Testing and Assessment (IATA) for regulatory toxicology assessment on May 28, 2020; event will be livestreamed, registration open

RIVM studies argue applied maximum doses too low

Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines

Study signifies potential toxicity of non-fluorinated surfactants

High-throughput screening of non-fluorinated aqueous firefighting foam finds they bind to key human protein as done by per- and polyfluoroalkyl substances (PFAS); suggests non-fluorinated alternatives may have similar toxicity pathway as PFAS

Immunomodulatory effects of EDCs

Scientists review studies reporting that some endocrine disrupting chemicals (EDCs) can affect development and functions of human immune cells; consequences include altered responses to infections and development of immune related diseases; food contact material (FCM)-relevant immunomodulatory EDCs include bisphenols, phthalates, triclosan