Online colloquium on IATA for toxicology assessment

Society of Toxicology (SOT) and US Food and Drug Administration (FDA) to co-host colloquium on Integrated Approaches to Testing and Assessment (IATA) for regulatory toxicology assessment on May 28, 2020; event will be livestreamed, registration open

RIVM studies argue applied maximum doses too low

Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines

Study signifies potential toxicity of non-fluorinated surfactants

High-throughput screening of non-fluorinated aqueous firefighting foam finds they bind to key human protein as done by per- and polyfluoroalkyl substances (PFAS); suggests non-fluorinated alternatives may have similar toxicity pathway as PFAS

Immunomodulatory effects of EDCs

Scientists review studies reporting that some endocrine disrupting chemicals (EDCs) can affect development and functions of human immune cells; consequences include altered responses to infections and development of immune related diseases; food contact material (FCM)-relevant immunomodulatory EDCs include bisphenols, phthalates, triclosan

Immunotoxicity testing for FCM assessment

FDA scientists review currently available tools, discuss how they might be used for developmental immunotoxicity assessment of food contact materials

FDA studies show short-chain PFAS toxicity, metabolite bioaccumulation

Scientists from the U.S. Food and Drug Administration (FDA) publish two studies on 6:2 fluorotelomer (6:2 FTOH); find risk posed by toxicity of 6:2 FTOH previously underestimated, acidic fluorotelomer metabolite bioaccumulates

FCM-relevant AOP research

Scientists explore adverse outcome pathways (AOPs) associated with bisphenols, phthalates, perchlorate, food additives, microplastics; discuss ways of using AOPs to predict chemical hazards, assess mixture toxicity

FPF Workshop 2019: Non-monotonicity explained

Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations

Using high-throughput screening data in FCM assessment

ILSI North America publishes case studies comparing U.S. EPA in vitro ToxCast data with in vivo toxicity data for food contact chemicals, identifies potential as well as challenges integrating high-throughput screening data into safety assessments

New BfR statement on polyamide oligomers

German risk assessment institute uses newly received toxicity data to establish group migration limit of 5mg/kg food for PA6 and PA66 oligomers