FCMs, gut health and risk assessment

New scientific article reviews food contact chemicals’ effects on gut permeability, microbiota, and immune responses; scientific justification for risk assessment assumptions questioned

Melamine’s effects beyond kidney

Scoping review identifies potential health effects of melamine other than renal damage, including impacts on neurological functions, behavior, reproduction, and growth

Utility of bioassays in safety assessment

Scientists demonstrate utility of bioassays in FCM safety assessment using 4-nonylphenol (4NP) as model substance; 4NP levels detected by bioassays considered relevant for safety assessment

High throughput in vitro testing of BPA analogues

Scientists analyze estrogen- and androgen-like properties of BPA analogues using cell-based high throughput microscopy-employing tests; demonstrate anti-estrogenic and anti-androgenic properties of TMBPF

In vitro testing of FCMs: Current science and future challenges

New scientific study by FPF summarizes research on alternative toxicity testing of FCMs, finds approach promising and feasible; sample preparation methods need to be optimized and standardized; employed assays should be of clear human health relevance

Phthalates’ impact on human health

Scientists compile comprehensive review on phthalates, focus on human health effects observed in epidemiological and clinical studies

Genotoxic chemicals in coatings

Scientists compile inventory of compounds potentially used in coatings; 1,976 substances have no (recent) toxicological evaluation; subset analyzed by in silico tools and literature search, 10 compounds designated as ‘high concern’

In vitro testing of paper and board FCMs

Scientists test paper and board FCMs in 8 in vitro bioassays; all 20 samples showed positive responses in at least one of the assays; chemicals in paper and board FCMs require further investigation to ensure safety

DEHP increases BPA exposure

Scientists show that diethylhexyl phthalate (DEHP) leads to higher accumulation of bisphenol A (BPA) in reproductive tissues of mice, likely due to competition for detoxification enzymes

New test methods for EDCs needed

JRC expert survey identifies gaps in test methods for evaluating endocrine disruptors; new methods for thyroid, metabolic, immune disorders, as well as hormone-related cancers seen as priority