EU discusses application of mixture assessment factor

Swedish and Dutch governments hold workshop investigating application of a mixture assessment factor for risk assessment under REACH legislation; ask EU member states for feedback, best procedure for way forward

Swedish report on future chemical management

Ministry of Environment report investigates improving management of hazardous chemicals by group, consideration of mixture toxicity in risk assessment; provides 11 recommendations for regulators; public comments accepted until May 29, 2020

Scientific consensus statement on food contact chemicals and human health

Group of 33 international scientists publish peer-reviewed statement identifying seven specific areas for improvement, urge decision makers to reduce exposure to harmful chemicals present in food packaging and other contact food contact materials

EFSA report: Human risk assessment for combined exposure

European Food Safety Authority (EFSA) publishes technical report outlining low tier risk assessment methodology for multiple regulated compounds with non-cancer effects; implements EFSA’s MIXTOX guidance document

EuroMix Project webinar series

Horizon 2020 research project on mixture risk assessment to hold series of five webinars; will provide understanding of the approach developed and demonstrate use of the published toolbox

EDC-MixRisk and EuroMix stakeholder workshop

Two EU funded research projects investigating chemical mixtures hold joint stakeholder workshop to present results, call for better consideration of mixtures in regulatory risk assessment and provide open-source tools for future research

EFSA publishes mixtures methodology

European Food Safety Authority launches guidance on assessment of ‘combined effects’ of chemical mixtures in food and feed

EFSA: Genotoxicity of mixtures

European Food Safety Authority publishes statement on genotoxicity assessment of chemical mixtures

Toxic effects of MOSH exposure

Dietary exposure of rats to mineral oil saturated hydrocarbons (MOSH) fractions similar to those accumulating in humans causes increase of liver and spleen weights; clinical significance needs further investigation

Science and practice of mixture assessment

Scientific means to assess chemical mixtures are available, but regulatory application lags behind due to practical challenges and lack of legal mandates