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Toxicological and chemical profiling of plastic migrates

Scientific study investigates in vitro toxicity and composition of chemical mixtures migrating from everyday plastic products made of eight polymer types; demonstrates that thousands of chemicals can leach under realistic use conditions, including compounds toxic in vitro that contribute to human exposure; emphasizes the importance to rethink and redesign plastics to achieve safe materials

Using ToxCast data to assess food chemicals

Scientists explore the utility of-throughput screening data for hazard assessment and toxicological read-across of food-relevant chemicals; observe some biological targets to lack validated toxicity associations; demonstrate application in identifying out-of-domain compounds

In vitro toxicity of bioplastics and plant-based materials

Scientists investigate in vitro toxicity of extracts from bioplastics and plant-based food contact articles; find strongest toxicity induced by cellulose- and starch-based products; emphasize similar toxicity profiles among bio-based, biodegradable, and conventional plastics

Benchmarking in vitro toxicity of plastics

Scientists investigate in vitro toxicity and chemical composition of plastic consumer products made of different polymers; high baseline toxicity of polylactic acid (PLA) bioplastics; food contact status does not necessarily imply lower toxicity

JRC: 2018 report on alternatives to animal testing

Joint Research Centre publishes annual 2018 report on ‘recent achievements and future plans’ in the field of development and regulatory acceptance of alternative approaches to animal testing

Testing for developmental neurotoxicity

Special issue of Toxicology and Applied Pharmacology features 18 articles discussing alternative (non-animal) methods for assessing chemicals’ potential to harm neurodevelopment in children

FPF Webinar on prioritizing potential genotoxics in FCMs

Register now for the Food Packaging Forum’s webinar on prioritization of potentially genotoxic substances in printed paper and board food contact materials, to be held on November 26, 2018

Ames test insufficient for genotoxicity of FCMs

Scientists deem Ames test unsuitable as standalone method to evaluate genotoxicity of FCM migrates, suggest complementing it with chemical information

FCM analysis at BioDetectors conference 2018

11th BioDetectors conference addresses use of cell-based bioassays in food contact material safety analysis

Mechanistic data in hazard assessment

Academic and industry scientists debate whether use of mechanistic data in regulatory hazard assessment of chemicals should be decisive or supportive only, discuss study selection process for systematic reviews

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