On June 14, 2013 the U.S. Environmental Protection Agency (EPA) finalized the first priority list (List 1) of 109 chemicals to undergo endocrine disruptor screening under the Endocrine Disruptor Screening Program (EDSP). The notice was published in the Federal Register (78 Fed. Reg. 35,922) and lists those chemicals that will undergo Tier 1 testing aimed at identifying chemicals with the potential to interact with the hormone system. The list consists of pesticides and chemicals occurring in drinking water. 29 of the listed substances are also authorized for food contact materials in the U.S. and/or Europe, according to an analysis by the Food Packaging Form. These chemicals include trichloroethane, vinylidene chloride, aniline and perchlorate.
The U.S. EPA selected chemicals based on a prioritization system focused on exposure potential, i.e. the likelihood for significant exposures to occur. The priority substances identified will undergo a two-tiered system primarily aiming at identification of a chemical’s potential to interact with the hormone system. In a second step other endocrine-related effects are determined, and the dose-response relationship is established.