In an article published in the August 2017 issue of the Endocrine Society’s news magazine Endocrine News, writer Kelly Horvath informed about three recent scientific studies providing further evidence on adverse health effects induced by exposure to endocrine disrupting chemicals (EDCs) bisphenol A (BPA, CAS 80-07-5) and bisphenol S (BPS, CAS 80-09-1).
The first study, published in the peer-reviewed journal Endocrinology and conducted by Harry MacKay and colleagues from Carleton University, Canada, reported on the impacts of early postnatal BPA-exposure on body weight, glucose homeostatis, and liver function in mice (FPF reported). The researchers found that exposure to low doses of BPA disrupts the regulation of feeding behavior and body weight.
The second study, presented at the Endocrine Society’s 2017 annual meeting (ENDO 2017) and conducted by Lindsey Starr Trevino and colleagues from Baylor College of Medicine, U.S., reported on the influence of BPA on the development of the liver in rodents. The researchers observed that early-life exposure to BPA makes rats prone to developing non-alcoholic liver disease (NAFLD) when exposed to a high-fat diet as adults.
The third study, also presented at ENDO 2017 and conducted by Katie Marie Aleck and colleagues from Oakland University, U.S., reported on the estrogenic activity of BPS, a commonly used substitute for BPA. The researchers found that BPS behaved like estrogen in two estrogen receptor (ER)-positive breast cancer cell lines, resulting in BPS-exposed cells to proliferate exponentially.
Kelly Horvath (August 2017). “No guarantees: Studies shed new light on the EDC potential of BPA & BPS.” Endocrine News
MacKay, H. et al. (2017). “Perinatal exposure to low-dose bisphenol-A (BPA) disrupts the structural and functional development of the hypothalamic feeding circuitry.” Endocrinology (published February 7, 2017).
Trevino, L.S. et al. (2017). “Early life environmental exposure creates ‘super-promoters’ by developmentally reprogramming the epigenome of genes associated with NAFLD.” (presented at ENDO 2017 on April 1, 2017).
Aleck, K.M. et al. (2017). “Regulation of estrogen receptor (ER) and BRCA1 by bisphenol-S (BPS) in breast cancer cells.” (presented at ENDO 2017 on April 1, 2017).