On October 1, 2013 the scientific peer-reviewed journal Endocrine Disruptors published a review by Laura Vandenberg, assistant professor at University of Massachusetts, Amherst, and colleagues. The researchers find effects of Bisphenol A (BPA) at 10 to 40 times lower doses than in traditional toxicological studies including doses at human exposure levels. The update to a 2007 review paper known as the Chapel Hill consensus statement evaluated hundreds of studies published since 2007. They detail in vitro and in vivo effects on polycystic ovarian syndrome, immune responses, behavioral problems and decrease fertility. The researchers conclude that doses at 1-4 orders of magnitude lower than the current U.S. lowest observed adverse effect level (LOAEL) of 50 mg/kg bw/day produce reproducible results.
Science Daily (November 7, 2013). “Bisphenol A Is Affecting Us at Much Lower Doses Than Previously Thought.”
Vandenberg, L. et al. (2013). “Low dose effects of bisphenol A: An integrated review of in vitro, laboratory animal, and epidemiology studies.” Endocrine Disruptors, 2013; 1 (1) DOI: 10.4161/endo.2649
Vom Saal, F. et al (2007). “Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure.” Reproductive Toxicology 24, 2, 131-138.