On May 22, 2014 the Cell Press published a press release pointing to a new technology testing the receptor activity of potential bisphenol A (BPA) substitutes (Stossi et al. 2014). The study published in the peer-reviewed scientific journal Chemistry & Biology presents high throughput microscopy-based assays allowing the evaluation of DNA binding, protein interactions, transcription, cell cycle and proliferation. Fabio Stossi of Baylor College of Medicine and lead author of the study states in the article that many of the currently used BPA analogues have not been thoroughly tested. The researchers studied BPA and 18 poorly researched BPA analogues including BPC, BPB, BPZ, BPF and BPS, and found many BPA analogues to have inhibitory effects on the estrogen receptor (ER)-β and stimulatory effect on the ER-α.
Cell Press (May 22, 2014). “New technology may help identify safe alternatives to BPA.” EurekAlert!
Stossi, F. et al. (2014). “Defining estrogenic mechanisms of bisphenol A analogs through high throughput microscopy-based contextual assays.” Chemistry & Biology (published online May 22, 2014).