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Research studies show maternal polystyrene (PS) particle exposure can cause testicular and hepatic toxicity in male mouse offspring; report PS microplastics affect rat ovary function; find correlation between human fecal microplastics levels and Inflammatory Bowel Disease; reviews summarize potential human health effects; study develops a tool to screen and prioritize micro-and nanoplastics toxicity studies for human health risks evaluation
Sublingual absorption leads to free BPA in serum of test animals, delivers plausible explanation for previous human biomonitoring findings
European Commission holds workshop with stakeholders to discuss criteria for chemicals that are Safe and Sustainable by Design (SSbD); implementation of EU’s Chemical Strategy for Sustainability (CSS) will depend on clear and implementable criteria for SSbD, amongst other central pillars such as essential use and generic risk assessment
Early life exposures to low doses of BPA studied in mice and linked to significant dose-dependent changes in animals’ biochemical response
Black thermocups and kitchen utensils contaminated with brominated flame retardants from illicit recycling practices
Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines
International negotiators prepare for first meeting to negotiate the UN treaty to end plastic pollution; scientists, civil society organizations, and governmental bodies publish reports proposing suggestions for what and how to negotiate; many reports support including controls on chemical additives as part of the treaty
First human biomonitoring study encounters plastic particles of four different polymer types in human blood; in vivo study reports polystyrene nanoparticles pass blood-brain barrier and induce neurotoxicity in mice; review summarizes plastic particle and titanium dioxide impacts on human gut epithelial integrity, gut homeostasis, and intestinal inflammation
Scientists find polystyrene microplastics reduce cell viability, translocate in the body, modify mice behavior, and change their liver and brain immune markers after short-term exposure; effects potentially age-dependent; two reviews summarize nano- and microplastic impacts on fertility and potential implications
Scientists discuss different cases of nonmonotonic dose-response curves and their relevance for regulatory decision-making; nonmonotonicity occurring at low doses challenges current approach to determining low-dose ‘safe’ exposure levels from high-dose toxicity testing
