On November 8, 2019, the U.S. Environmental Protection Agency (EPA) announced a 45-day public comment period for the systematic review protocol for Integrated Risk Information System (IRIS) assessments of five per- and polyfluoroalkyl substances (PFAS). These include: perfluorodecanoic acid (PFDA; CAS 335-76-2), perfluorononanoic acid (PFNA; CAS 375-95-1), perfluorohexanoic acid (PFHxA; CAS 307-24-4), perfluorohexanesulfonate (PFHxS; CAS 355-46-4), and perfluorobutanoic acid (PFBA; CAS 456-22-4). News provider Chemical Watch reported that the EPA aims for the protocols to be published early in the assessment process to “increase transparency” and clarify how the assessments will be run. The comment period is open until December 23, 2019.

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EPA (November 8, 2019). “Availability of the Systematic Review Protocol for the PFDA, PFNA, PFHxA, PFHxS, and PFBA IRIS Assessments.”

Amanda Ulrich (November 12, 2019). “US EPA publishes review protocol for five PFAS toxicity assessments.” Chemical Watch


EPA (November 8, 2019). “Systematic Review Protocol for the Pfas IRIS Assessments.”