In a research article published in the journal Food and Chemical Toxicology, Alexandra Turley and co-authors conducted risk assessment case studies that compared ToxCast data from the U.S. Environmental Protection Agency (EPA) with in vivo toxicity data for two food contact chemicals using the RISK21 approach, which advocates for harmonized chemical evaluations using a risk-based approach. Available data describing exposure, toxicity, and model predictions for the substances sodium (2-pyridylthio)-N-oxide (CAS 3811-73-2) and dibutyltin dichloride (CAS 683-18-1) were assessed. The study aimed to help develop best approaches to interpret the large amounts of in vitro high-throughput screening (HTS) data coming out of programs such as ToxCast.
The authors found that results from the study highlight “the potential utility of the RISK21 approach for interpretation of the ToxCast HTS data, as well as the challenges involved in integrating in vitro HTS data into safety assessments.”
Turley, A.E. et. al. (2019). “Incorporating new approach methodologies in toxicity testing and exposure assessment for tiered risk assessment using the RISK21 approach: Case studies on food contact chemicals” Food and Chemical Toxicology 134. DOI: 10.1016/j.fct.2019.110819