In an article published on October 12, 2017, regulatory news provider Chemical Watch informed that studies on five suspected endocrine disrupting chemicals (EDCs), carried out in 2016 by the French Agency for Food, Environmental and Occupational Health and Safety (ANSES), revealed a “significant lack of data,” thereby preventing the agency from making a conclusion on the possible endocrine disrupting properties of these chemicals.
One of the five chemicals assessed by ANSES was tetramethyl bisphenol F (TMBPF, CAS 5384-21-4). This chemical, developed to serve as an alternative to bisphenol A (BPA, CAS 80-05-7) for making can coating resins in particular, was demonstrated to lack the estrogenic activity characteristic of BPA, both in vitro and in vivo (FPF reported). A later study, however, reported anti-estrogenic and anti-androgenic activity of TMBPF in vitro (FPF reported).
In its report, ANSES said that it was “unable to rule out TMBPF as an EDC.” This chemical “may have an anti-androgenic effect, or affect signaling via estrogen receptors,” the agency suggested. ANSES further recommended that data on genotoxicity and reprotoxicity of this chemical should be requested.
In 2017, ANSES’ assessment will focus on five further chemicals, among them bisphenol B (CAS 77-4-7) and 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47, CAS 5436-43-1).
Chemical Watch (October 12, 2017). “Lack of data prevents ANSES from concluding on five possible EDCs.”
ANSES (2017). “AVIS de l’Agence nationale de sécurité sanitaire de l’alimentation, de l’environnement et du travail relatif à l’évaluation des substances inscrites au programme de travail 2016 de l’Agence dans le cadre de la Stratégie nationale sur les perturbateurs endocriniens (SNPE) : triclocarban (n°CAS 101-20-2), sulfate d’étain (n°CAS 7488-55-3), dicyclopentadiène (n°CAS 77-73-6), RDP (Tétraphényl m-phénylène bis(phosphate)) (n°CAS 57583-54-7) et TMBPF (4,4’-méthylènedi-2,6-xylénol) n°CAS 5384-21-4).” (pdf; in French)