In an article published on July 11, 2019, by regulatory news provider Chemical Watch, reporter Emma Davies informed that currently “the European Commission’s [(EC)] Joint Research Centre (JRC) is running a survey to assess how stakeholders use mechanistic information from non-animal methods for chemical risk assessment.”

The survey aims to “gauge familiarity” with the concept of adverse outcome pathways (AOPs) and with the AOP knowledge base (AOP-KB) tool developed by the Organization for Economic Cooperation and Development (OECD) together with several partners (FPF reported). Further, the JRC plans to use the survey’s results to understand how to further develop the AOP framework so that it could “serve regulatory priorities now and in the future.”

Davies also pointed out that the Global Chemicals Outlook II report, published by the United Nations Environment Programme in April 2019 (FPF reported), has specifically “recommended that stakeholders ‘accelerate’ developing the AOP concept to support hazard assessment.” A review published in 2018 highlighted that “the potential stakeholder community for the AOP concept and the AOP-KB is ‘broader than scientists and regulators directly involved in chemical safety assessment.’”

Read more

Emma Davies (July 11, 2019). “JRC launches adverse outcome pathway survey.Chemical Watch


Carusi, A., et al. (2018). “Harvesting the promise of AOPs: An assessment and recommendations.Science of the Total Environment 628-629: 1542-1556.