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Standardizing Benchmark Dose (BMD) calculations
New study assesses reliability of standardized Benchmark Dose calculations, more dose groups and lower number of animals make for better BMD model
Regulatory relevance of nonmonotonic responses
Scientists discuss different cases of nonmonotonic dose-response curves and their relevance for regulatory decision-making; nonmonotonicity occurring at low doses challenges current approach to determining low-dose ‘safe’ exposure levels from high-dose toxicity testing
Adverse health effects of low-dose mixtures
Scientists evaluate health effects of a mixture of 27 environmental chemicals in rats exposed to low concentrations comparable to current human exposure levels; find effects on weight, histology, gene expression in the liver, and metabolome of blood plasma
Ukraine aligning FCM regulations with EU
Ukraine’s Ministry of Health notifies World Trade Organization of a draft restriction on vinyl chloride in contact with food; restriction aligns with a 1978 European Council declaration on vinyl chloride in food contact materials (FCMs); ministry announces other alignments including on migration of lead and cadmium from ceramic FCMs
Plastics policy in the UK needs clarity and reform
Greenpeace and Everyday Plastic publish results from voluntary plastic waste audit of nearly 100,000 UK homes; finds UK households throw away nearly 100 billion pieces of plastic a year, 83% of which is from food and drinks; waste organizations within the country ask for stronger policies and more clarity on existing goals
Canada to ban single-use plastics
Development of action plan announced for Canada-wide Strategy on Zero Plastic Waste; ban to focus on reducing plastic pollution, aims to begin by 2021 but details still to be finalized
Canada continues single-use plastics ban, England considers similar action
Canada moves forward with domestic ban of six single-use plastic products; targets checkout bags, cutlery, foodservice ware, ring carriers, stir sticks, and straws; ban may come into force before end of 2022; public consultation until March 5, 2022; England considering similar ban with consultation until February 12, 2022
Global Food Contact Conference 2022: updates from the Americas
Smithers conference covers global developments in food contact regulations and materials; speakers on day one review recent and upcoming changes to food packaging regulations in the US, Canada, and the South American trade bloc Mercosur
RIVM studies argue applied maximum doses too low
Researchers from Dutch National Institute for Public Health and the Environment (RIVM) publish two peer-reviewed articles critically reviewing determination and application of maximum doses in toxicity studies; find that recent toxicity studies increasingly using unjustified low maximum doses, call for more clarity in testing guidelines