Webinar on non-monotonicity of BPA

Food Packaging Forum holds webinar featuring presentation from researchers at Tufts University, discusses recent study observing non-monotonic dose-responses in mammary gland development of rats from exposure to bisphenol A (BPA)

CLARITY-BPA study finds clear non-monotonicity

Researchers publish study identifying non-monotonic effects on mammary gland development across all ages of rats; finds causal relationship between BPA exposure and effects observed, results counter earlier statements that effects are rather due to random events

FPF Workshop 2019: Non-monotonicity explained

Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations

Assessment of EDC authorizations by ECHA

European Chemicals Agency to work on authorization applications for octylphenol and nonylphenol ethoxylates; both threshold and non-threshold assessment approaches can be considered

Rethinking safe levels

Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity

Evidence on BPA’s ubiquity and low-dose effects

New study reviews and substantiates ubiquitous occurrence of bisphenol A in the environment and adverse health effects from low-dose exposures to it

Extranuclear actions of EDCs at low doses

Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha, beta, and membrane-associated forms of estrogen receptor

Are ‘safe levels’ safe?

Article questions effectiveness of current chemical risk assessment in protecting public health; explains non-monotonic dose response and why it should be considered in assessing chemicals’ toxicity

EFSA: Non-monotonic dose response update

EFSA-commissioned review of non-monotonic dose response (NMDR) studies published; four substances relevant to food safety identified with potential for NMDR effects

Manmade vs. natural estrogens

Article in Nature Reviews highlights different effect potential of manmade vs. natural estrogens in the case of soy and bisphenol A in a study with women undergoing in vitro fertilization