Tackling the toxics in plastics packaging

Article in PLOS Biology discusses hazardous chemicals in plastics; highlights chemicals as critical but often missing aspect in plastic pollution discussion; proposes rethinking current approach to plastic packaging toxicity testing

FPF comments on EFSA’s non-monotonic dose response opinion

Scientific Committee’s Scientific Opinion fails to deliver on European Food Safety Authority’s (EFSA) commitment to scientific excellence and transparency; Food Packaging Forum (FPF) sends open letter to EFSA’s leadership urging them to address severe shortcomings in content and process; adequate scientific appraisal of non-monotonic dose response (NMDR) is critical for chemical risk assessment that protects public health

Second episode of ‘Unwrapping Food Packaging’ video blog released

Food Packaging Forum publishes second episode of new video blog; discusses if low levels of chemicals migrating from food packaging are safe; introduces viewers to the concepts of non-monotonic dose response, endocrine disrupting chemicals, mixture toxicity, and timing of exposure

EFSA: Draft opinion on NMDR open for consultation

European Food Safety Authority’s (EFSA) draft opinion reviews literature on assessment of non-monotonic dose responses (NMDRs), finds lack of standards for statistical approaches; suggests stepwise approach for ambiguous ‘apparent’ NMDRs; approach applied in two case studies finds no NMDR for bisphenol A (BPA) but does for di(2-ethylhexyl)phthalate (DEHP); open for comments until February 4, 2021

Webinar on non-monotonicity of BPA

Food Packaging Forum holds webinar featuring presentation from researchers at Tufts University, discusses recent study observing non-monotonic dose-responses in mammary gland development of rats from exposure to bisphenol A (BPA)

CLARITY-BPA study finds clear non-monotonicity

Researchers publish study identifying non-monotonic effects on mammary gland development across all ages of rats; finds causal relationship between BPA exposure and effects observed, results counter earlier statements that effects are rather due to random events

FPF Workshop 2019: Non-monotonicity explained

Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations

Assessment of EDC authorizations by ECHA

European Chemicals Agency to work on authorization applications for octylphenol and nonylphenol ethoxylates; both threshold and non-threshold assessment approaches can be considered

Rethinking safe levels

Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity

Evidence on BPA’s ubiquity and low-dose effects

New study reviews and substantiates ubiquitous occurrence of bisphenol A in the environment and adverse health effects from low-dose exposures to it