Food Packaging Forum holds webinar featuring presentation from researchers at Tufts University, discusses recent study observing non-monotonic dose-responses in mammary gland development of rats from exposure to bisphenol A (BPA)
May 22, 2020
CLARITY-BPA study finds clear non-monotonicity
Researchers publish study identifying non-monotonic effects on mammary gland development across all ages of rats; finds causal relationship between BPA exposure and effects observed, results counter earlier statements that effects are rather due to random events
April 5, 2019
Assessment of EDC authorizations by ECHA
European Chemicals Agency to work on authorization applications for octylphenol and nonylphenol ethoxylates; both threshold and non-threshold assessment approaches can be considered
December 20, 2017
Rethinking safe levels
Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity
August 8, 2017
Evidence on BPA’s ubiquity and low-dose effects
New study reviews and substantiates ubiquitous occurrence of bisphenol A in the environment and adverse health effects from low-dose exposures to it
February 10, 2017
Extranuclear actions of EDCs at low doses
Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha, beta, and membrane-associated forms of estrogen receptor
June 29, 2016
Are ‘safe levels’ safe?
Article questions effectiveness of current chemical risk assessment in protecting public health; explains non-monotonic dose response and why it should be considered in assessing chemicals’ toxicity
May 4, 2016
EFSA: Non-monotonic dose response update
EFSA-commissioned review of non-monotonic dose response (NMDR) studies published; four substances relevant to food safety identified with potential for NMDR effects
March 30, 2016
Manmade vs. natural estrogens
Article in Nature Reviews highlights different effect potential of manmade vs. natural estrogens in the case of soy and bisphenol A in a study with women undergoing in vitro fertilization