Topic

non-monotonic dose-response

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October 29, 2019

FPF Workshop 2019: Non-monotonicity explained

Ana Soto presents biological mechanisms underlying non-monotonic dose-responses, explains why non-monotonicity is ‘useful to organisms, challenging for regulators,’ discusses CLARITY-BPA’s successes and limitations

Topics: bisphenol A, diabetes, endocrine disruptor, metabolic disruptor, non-monotonic dose-response, regulation, risk assessment, toxicity testing

April 5, 2019

Assessment of EDC authorizations by ECHA

European Chemicals Agency to work on authorization applications for octylphenol and nonylphenol ethoxylates; both threshold and non-threshold assessment approaches can be considered

Topics: endocrine disruptor, exposure, non-monotonic dose-response, risk assessment

December 20, 2017

Rethinking safe levels

Scientific review shows that some chemicals are proportionately more toxic at lower exposure levels; “dose makes poison” principle indicates that current risk assessment approaches underestimate chemical toxicity

Topics: chronic disease, exposure, non-monotonic dose-response, toxicity testing

August 8, 2017

Evidence on BPA’s ubiquity and low-dose effects

New study reviews and substantiates ubiquitous occurrence of bisphenol A in the environment and adverse health effects from low-dose exposures to it

Topics: bisphenol A, endocrine disruptor, exposure, low dose, non-monotonic dose-response

February 10, 2017

Extranuclear actions of EDCs at low doses

Scientists review molecular mechanisms underlying low-dose actions of estrogenic EDCs, focusing on extranuclear signaling; BPA effects in pancreas and heart mediated through alpha, beta, and membrane-associated forms of estrogen receptor

Topics: bisphenol A, bisphenol S, endocrine disruptor, low dose, non-monotonic dose-response, toxicity testing

June 29, 2016

Are ‘safe levels’ safe?

Article questions effectiveness of current chemical risk assessment in protecting public health; explains non-monotonic dose response and why it should be considered in assessing chemicals’ toxicity

Topics: endocrine disruptor, mixture toxicity, non-monotonic dose-response, risk assessment, toxicity testing

May 4, 2016

EFSA: Non-monotonic dose response update

EFSA-commissioned review of non-monotonic dose response (NMDR) studies published; four substances relevant to food safety identified with potential for NMDR effects

Topics: EFSA, endocrine disruptor, non-monotonic dose-response, risk assessment

March 30, 2016

Manmade vs. natural estrogens

Article in Nature Reviews highlights different effect potential of manmade vs. natural estrogens in the case of soy and bisphenol A in a study with women undergoing in vitro fertilization

Topics: bisphenol A, endocrine disruptor, food, low dose, non-monotonic dose-response

December 1, 2015

Opinions: Toxic chemicals in everyday products

Article in New York Times outlines the issue of exposure to toxic chemicals from common products and the consequences for human health

Topics: chronic disease, development, diabetes, endocrine disruptor, epidemiology, exposure, flame retardants, low dose, mixture toxicity, non-monotonic dose-response, obesity, prenatal, regulation

November 9, 2015

2^nd Scientific Statement on EDCs released

Endocrine Society summarizes EDC research of the past six years and links EDC exposure to various health problems

Topics: bisphenol A, chronic disease, development, diabetes, endocrine disruptor, epidemiology, exposure, low dose, non-monotonic dose-response, obesity, phthalates, prenatal, thyroid

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